Most male infertility problems arise due to the following reasons:
Genital tract disorders
Genital tract disorders prevent semen from being deposited in the vagina during intercourse (erectile impotence, absence of ejaculation). In addition, there could be an anomalous situation of the urinary meatus, such as:
- If it is below its normal location (hypospadias) or above it (epispadias)
- If the penis has a curvature that is too pronounced or a decrease in its size, and
- Obesity and other erection problems, premature or delayed ejaculation and other ejaculation problems that can also prevent the spermatozoa from being adequately deposited in the vagina.
Alterations in semen production
Low production of semen is one of the predominant causes of infertility in males. Semen may contain few spermatozoa (oligozoospermia) or no spermatozoa (azoospermia) due to problems in its production in the testicles. The main causes for low semen production are due to:
- Disorder of the brain glands (hypophysis and hypothalamus) that produce the hormones regulating the formation of spermatozoa
- Genetic disorders (Klinefelter syndrome, alteration of genes contained in the Y-chromosome that regulates the formation of spermatozoa, etc.)
- A number of testicular problems, such as underdevelopment, anomalous development, failure to descend into the scrotum (cryptorchidism), trauma, and inflammations (whether sexually transmitted or otherwise), tumors, exposure to toxic substances, chemotherapy and radiotherapy and varicocele.
Spermatozoa may be absent or present in very low numbers in semen because of the obstructions in their path from the testicles to the urethra owing to:
- Absence of part of the conduits (frequently associated with the cystic fibrosis gene)
- Involuntary surgical lesions
Spermatozoa can also show anomalies in their motility (astenozoospermia), shape (teratozoospermia) or vitality (Necrozoospermia) due to different causes relating to infections, presence of antibodies (which act against spermatozoa), DNA fragmentation (genetic material contained in the spermatozoid’s head), oxidation phenomena, varicocele (anomalous dilation of veins that come out mainly from the left testicle).
The quality and count of the sperms can also be affected by major diseases such as diabetes, thyroid disorders, kidney disease and hepatic insufficiency, as well as the intake of certain medications, tobacco and stress.
The main cause of male infertility is low semen quality. In men who have the necessary reproductive organs to procreate, infertility can be caused by low sperm count due to endocrine problems, drugs, radiation, or infection. There may be testicular malformations, hormone imbalance, or blockage of the man’s duct system. Although many of these can be treated through surgery or hormonal substitutions, some may be more indefinite. Infertility associated with viable, but immotile sperm may be caused by primary ciliary dyskinesia.
Some men find that low sperm count or poor sperm quality make them somehow ‘’Less of man’’. Men may experience profound feelings of guilt, anger and low self esteem, which can affect all aspects of lives. Like factors for Male infertility
- Abnormal body weight
- Alcohol and Drug
- Gutka, Pan Parag and Tobacco chewing
- High Cholesterol
- Environmental factor
- Heat Exposure
Today exciting advances in male infertility have introduced innovative therapeutic options that offer men including those with no sperm in their ejaculate due to genetic conditions,a greatly improved chance to conceive their own Biological child with procedures of TESA or PESA at our Universal Test Tube Centre .We provide the best possible chances for conceiving a child who seeks treatment for Infertility.
We provide procedure like TESA, PESA, and ICSI at our centre.
SQA, Culture, survival of sperm, ASA and sperm function Tests available, DNA fragmentation tests available. In frequent failures of ICSI cases Y-chromosome deletions may be expect.
NGS (Next Generation Sequencing) is available with us to find out the causes of single gene disorders, gene mutations in 23 chromosomes.